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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACO1
All Species:
38.18
Human Site:
T858
Identified Species:
60
UniProt:
P21399
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21399
NP_002188.1
889
98399
T858
V
K
L
D
T
G
K
T
F
Q
A
V
M
R
F
Chimpanzee
Pan troglodytes
XP_001155934
889
98362
T858
V
K
L
D
T
G
K
T
F
Q
A
V
M
R
F
Rhesus Macaque
Macaca mulatta
XP_001103675
889
98487
T858
V
K
L
D
T
G
K
T
F
Q
V
V
M
R
F
Dog
Lupus familis
XP_538698
889
98299
T858
V
Q
L
D
S
G
K
T
F
Q
A
I
M
R
F
Cat
Felis silvestris
Mouse
Mus musculus
P28271
889
98160
T858
I
K
L
D
T
G
K
T
F
Q
A
V
M
R
F
Rat
Rattus norvegicus
Q63270
889
98109
T858
I
K
L
D
T
G
K
T
F
Q
A
V
M
R
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509375
889
98624
T858
I
K
L
D
T
G
K
T
F
E
A
V
M
R
F
Chicken
Gallus gallus
Q90875
889
98055
T858
I
K
L
D
T
G
K
T
F
H
A
I
M
R
F
Frog
Xenopus laevis
Q6NTP2
955
104418
I925
I
K
T
N
T
G
K
I
F
H
V
I
A
A
F
Zebra Danio
Brachydanio rerio
NP_001030155
890
98920
T858
I
K
L
D
T
G
K
T
F
Q
A
R
M
R
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524303
899
98560
V868
Q
V
E
A
D
G
T
V
F
E
T
I
L
R
F
Honey Bee
Apis mellifera
XP_392993
890
98796
R860
V
S
T
D
N
G
K
R
F
E
V
I
L
R
F
Nematode Worm
Caenorhab. elegans
Q23500
887
96642
V856
V
N
V
S
N
G
S
V
F
Q
V
I
C
R
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIB9
990
108183
S958
V
T
T
D
N
G
K
S
F
T
C
T
V
R
F
Baker's Yeast
Sacchar. cerevisiae
P19414
778
85350
P746
V
H
P
K
N
G
K
P
W
D
A
V
L
T
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.9
93.2
N.A.
93.4
92.9
N.A.
90.4
87.5
55.7
82.2
N.A.
67.9
69.4
62.9
N.A.
Protein Similarity:
100
100
99.5
96.9
N.A.
97.7
97.7
N.A.
95.1
93.8
72.2
92
N.A.
82.1
82.5
77.1
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
93.3
93.3
N.A.
86.6
80
40
86.6
N.A.
26.6
46.6
40
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
100
93.3
60
93.3
N.A.
46.6
66.6
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
55.6
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
69.6
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
0
0
0
60
0
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% C
% Asp:
0
0
0
74
7
0
0
0
0
7
0
0
0
0
0
% D
% Glu:
0
0
7
0
0
0
0
0
0
20
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
94
0
0
0
0
0
94
% F
% Gly:
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
14
0
0
0
0
7
% H
% Ile:
40
0
0
0
0
0
0
7
0
0
0
40
0
0
0
% I
% Lys:
0
60
0
7
0
0
87
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
60
0
0
0
0
0
0
0
0
0
20
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
60
0
0
% M
% Asn:
0
7
0
7
27
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% P
% Gln:
7
7
0
0
0
0
0
0
0
54
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
7
0
0
0
7
0
87
0
% R
% Ser:
0
7
0
7
7
0
7
7
0
0
0
0
0
0
0
% S
% Thr:
0
7
20
0
60
0
7
60
0
7
7
7
0
7
0
% T
% Val:
54
7
7
0
0
0
0
14
0
0
27
47
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _